Vitamin B complex is essential for a wide variety of functions in the human body, Its deficiency can also lead to several disorders including chronic neurological ones. Biochemically, different structures are grouped together under B complex on the basis of their natural occurrence in same type of food and solubility in water. Since humans are not able to synthesize vitamins in B complex on their own and these vitamins are easily excreted from the body through urine, their regular intake is essential to maintain energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation as well as synthesis of numerous neurochemicals and signaling molecules. B complex deficiency is normally caused due to four possible reasons; high consumption of processed and refined food, with lack of dairy and meat-based food in diet, excessive consumption of alcohol, impaired absorption from the gastrointestinal tract or impaired storage and use by liver.
According to clinical research parenteral administration (intramuscular or intravenous) is preferred over other drug administration routes in case of emergency situations as it provides first-pass metabolism avoidance, reliable therapeutic concentrations and better bioavailability of dosage. It can also be used in situations when oral route is not feasible.
Each 30 mL vial contains: 100 mg of vitamin B1 in form of thiamine hydrochloride, 2 mg of vitamin B2 in form riboflavin-5-phosphate sodium, 100 mg of B3 in form niacinamide, 2 mg of vitamin B5 in form of dexpanthenol and 2 mg of vitamin B6 in form of pyridoxine hydrochloride.
B vitamins are necessary for the proper functioning of the methylation cycle, DNA synthesis, repair and maintenance of phospholipids and generally essential for healthy skin, muscles, brain, and nerve functionality. The individual functions are described below but more often than not they work together to achieve the required effect.
Vitamin B1 (Thiamine HCl)
It plays an important role in energy metabolism, immunity boosting and functioning of nervous system. It can help avoid type 2 diabetes, several cardiovascular diseases, some vision and kidney disorders and neurodegenerative diseases like Alzheimer’s disease.
Vitamin B2 (Riboflavin-5-Phosphate Sodium)
It is a powerful antioxidant and plays a vital role in maintaining healthy blood cells and boosts metabolism.
Vitamin B3 (Niacinamide)
Niacin plays a critical role in proper functioning of the nervous and digestive systems. Like other vitamins from the family it is necessary for energy production and metabolism of fatty acids. It also provides healthy skin, nails, and hair.
Vitamin B5 (Dexpanthenol)
Pantothenic acid is essential for healthy development of the central nervous system. It is involved in energy production and through different metabolic and anabolic cycles in development of amino acids, blood cells, vitamin D3 and other fatty acids.
Vitamin B6 (Pyridoxine HCl)
Vitamin B6 has a very influential role in synthesis of neurotransmitters and is essential for good mental health. It also has a direct effect on immune function. It plays a role in metabolism of amino acids and is a necessary co-factor in the folate cycle, lack of which can lead to anaemia.
Epidemiological evidence in some cases hints that the accepted dosages of vitamin B helps only to avoid their marginal deficiency and further benefits could accrue from higher dosages than those provided by RDA.