No absolute contraindications to riboflavin (vitamin B2) use are known.
Appropriate maternal riboflavin (vitamin B2) intake is encouraged during pregnancy (FDA pregnancy risk category A). The pregnancy risk factor increases to FDA risk category C if the vitamin is used in dosages exceeding the recommended RDA during pregnancy. Adverse effects have not been reported with the normal daily intake of riboflavin within the recommended dietary daily intakes for a pregnant female. The use of riboflavin in excess of the recommended dietary allowance during normal pregnancy should be avoided unless, in the judgment of the physician, potential benefits in a specific, unique case outweigh the significant hazards involved.
Appropriate maternal intake of riboflavin (vitamin B2) is important during lactation. The American Academy of Pediatrics has considered the use of riboflavin compatible with breastfeeding. Use of riboflavin within the recommended daily dietary intake for lactating women is generally recognized as safe. Consider the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breastfeeding infant experiences an adverse effect related to a maternally administered drug, healthcare providers are encouraged to report the adverse effect to the FDA.