Glycine is, structurally, the simplest amino acid that has been discovered. It was one of the earliest amino acids to be isolated from gelatin back in 1820. Glycine is one of the nonessential amino acids for mammals; meaning that they can create it internally from two other amino acids: serine and threonine.https://www.calstatela.edu/sites/default/files/dept/chem/07summer/158/25-words-glycine.pdf
Glycine is found principally in gelatin and silk fibroin. It’s been used therapeutically as a nutrient, and also functions as a rapid inhibitory neurotransmitter in the central nervous system (CNS).National Center for Biotechnology Information. PubChem Compound Database; CID=750, https://pubchem.ncbi.nlm.nih.gov/compound/750 (accessed Oct. 6, 2017). Although glycine is both a simple and nonessential amino acid; experimental animals on low-glycine diets show reduced growth.https://www.calstatela.edu/sites/default/files/dept/chem/07summer/158/25-words-glycine.pdfNational Center for Biotechnology Information. PubChem Compound Database; CID=750, https://pubchem.ncbi.nlm.nih.gov/compound/750 (accessed Oct. 6, 2017). The average adult will ingest 3 to 5 grams of glycine daily from dietary sources. https://www.calstatela.edu/sites/default/files/dept/chem/07summer/158/25-words-glycine.pdf Glycine is an amino acid that’s involved in the production of DNA, phospholipids, and collagen. It’s also involved in the release of energy.Guo, Zhi-li et al. “DanHong Injection Dose-Dependently Varies Amino Acid Metabolites and Metabolic Pathways in the Treatment of Rats with Cerebral Ischemia.” Acta Pharmacologica Sinica 36.6 (2015): 748–757. PMC. Web. 6 Oct. 2017.
People being treated with clozapine should avoid taking glycine.Schwieler L, Linderholm KR, Nilsson-Todd LK, Erhardt S, Engberg G. Clozapine interacts with the glycine site of the NMDA receptor: electrophysiological studies of dopamine neurons in the rat ventral tegmental area. Life Sci. 2008 Aug 1;83(5-6):170-5. doi: 10.1016/j.lfs.2008.05.014. Epub 2008 Jun 10.
A small number of individuals have reported experiencing slight sedation after using glycine.Gusev EI, Skvortsova VI, Dambinova SA, Raevskiy KS, Alekseev AA, Bashkatova VG, Kovalenko AV, Kudrin VS, Yakovleva EV. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis. 2000 Jan-Feb;10(1):49-60.
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond-use date. Do not flush unused medications or pour down a sink or drain.