Dexpanthenol is a synthetic derivative of pantothenic acid, a B complex vitamin that is widely distributed in plants and animals. Dexpanthenol is used parenterally as a gastrointestinal stimulant to treat and prevent ileus after GI surgery and in other conditions with impaired GI activity. Dexpanthenol was approved by the FDA in 1948.
Some rare cases of allergic reactions have been reported when taking dexpanthenol injection in combination with drugs such as antibiotics, narcotics, and barbiturates.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Use dexpanthenol only if clearly needing during pregnancy; animal reproductive studies have not been conducted. Dexpanthenol is a FDA pregnancy risk category C drug.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
It is not known whether dexpanthenol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when dexpanthenol is administered to a woman who is breast-feeding.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
Use caution in the management of adynamic ileus which may include the correction of any fluid and electrolyte imbalance (especially hypokalemia), anemia and hypoproteinemia, treatment of infection, and avoidance of drugs which are known to decrease gastrointestinal motility.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
If the ileus is secondary to a mechanical GI obstruction, primary attention should be directed to treating the obstruction.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Use dexpanthenol only if clearly needing during pregnancy; animal reproductive studies have not been conducted. Dexpanthenol is a FDA pregnancy risk category C drug.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
It is not known whether dexpanthenol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when dexpanthenol is administered to a woman who is breastfeeding.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July Consider the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breastfeeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
Acetaminophen; Butalbital; Caffeine; Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Acetaminophen; Caffeine; Dihydrocodeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Acetaminophen; Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Acetaminophen; Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Acetaminophen; Oxycodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Acetaminophen; Propoxyphene: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Alfentanil: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Aspirin, ASA; Butalbital; Caffeine; Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Aspirin, ASA; Caffeine; Dihydrocodeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Aspirin, ASA; Carisoprodol; Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Aspirin, ASA; Oxycodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Belladonna; Opium: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Brompheniramine; Guaifenesin; Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Brompheniramine; Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Carbinoxamine; Hydrocodone; Phenylephrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Carbinoxamine; Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Dihydrocodeine; Phenylephrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Dihydrocodeine; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Hydrocodone; Phenylephrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Chlorpheniramine; Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Codeine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of `dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Codeine; Guaifenesin: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Codeine; Phenylephrine; Promethazine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Codeine; Promethazine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Dihydrocodeine; Guaifenesin; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Diphenhydramine; Hydrocodone; Phenylephrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Fentanyl: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Guaifenesin; Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Guaifenesin; Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Homatropine; Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone; Ibuprofen: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone; Phenylephrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone; Potassium Guaiacolsulfonate: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydrocodone; Pseudoephedrine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Hydromorphone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Ibuprofen; Oxycodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Levorphanol: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Meperidine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Meperidine; Promethazine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Methadone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Morphine: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Morphine; Naltrexone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Opiate Agonists: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Oxycodone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Oxymorphone: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Propoxyphene: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Remifentanil: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Succinylcholine: (Minor) The effects of succinylcholine may be prolonged with dexpanthenol administration. It is recommended to separate doses of dexpanthenol and succinylcholine by at least 1 hour to decrease the potential for this effect.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Sufentanil: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
There was a case report of respiratory depression following dexpanthenol administration.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Two patients experienced vomiting and diarrhea in the days following surgery and dexpanthenol administration.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
There are minimal case reports of allergic reactions such as pruritus, urticaria, rash (unspecified), tingling, and difficulty breathing. If this occurs, dexpanthenol should be discontinued.Dexpanthenol package insert. Shirley, NY: American Regent, Inc.; 2006 July
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond-use date. Do not flush unused medications or pour down a sink or drain.
